{"id":6626,"date":"2024-06-24T05:13:32","date_gmt":"2024-06-24T12:13:32","guid":{"rendered":"https:\/\/highfieldbio.com\/?p=6626"},"modified":"2024-12-18T06:18:05","modified_gmt":"2024-12-18T14:18:05","slug":"highfield-biopharmaceuticals-mrna-based-hfg1-demonstrates-potential-as-a-longer-acting-glp-1r-agonist-for-diabetic-control-and-weight-loss","status":"publish","type":"post","link":"https:\/\/highfieldbio.com\/zh\/2024\/06\/24\/highfield-biopharmaceuticals-mrna-based-hfg1-demonstrates-potential-as-a-longer-acting-glp-1r-agonist-for-diabetic-control-and-weight-loss\/","title":{"rendered":"HighField Biopharmaceuticals \u57fa\u4e8e mRNA \u7684 HFG1 \u663e\u793a\u51fa\u4f5c\u4e3a\u957f\u6548 GLP-1R \u6fc0\u52a8\u5242\u7528\u4e8e\u63a7\u5236\u7cd6\u5c3f\u75c5\u548c\u51cf\u80a5\u7684\u6f5c\u529b"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"6626\" class=\"elementor elementor-6626\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7c3df96 elementor-section-boxed elementor-section-height-default elementor-section-height-default smart-sticky-default\" data-id=\"7c3df96\" data-element_type=\"section\">\r\n\t\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\r\n\t\t\t\t\r\n\t\t\t\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f09d554\" data-id=\"f09d554\" data-element_type=\"column\">\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\r\n\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-33706a9 elementor-widget elementor-widget-spacer\" data-id=\"33706a9\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f9ed22 elementor-widget elementor-widget-udesign_widget_heading\" data-id=\"7f9ed22\" data-element_type=\"widget\" data-widget_type=\"udesign_widget_heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"title-wrapper  title-cross title-center\"><p class=\"title elementor-heading-title\">2024 \u5e74 6 \u6708 24 \u65e5 | HighField Bio \u65b0\u95fb\u7a3f<\/p><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b2ac3db elementor-widget elementor-widget-spacer\" data-id=\"b2ac3db\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ac618a2 elementor-widget elementor-widget-udesign_widget_heading\" data-id=\"ac618a2\" data-element_type=\"widget\" data-widget_type=\"udesign_widget_heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"title-wrapper  title-center\"><h2 class=\"title elementor-heading-title\">HighField Biopharmaceuticals \u57fa\u4e8e mRNA \u7684 HFG1 \u663e\u793a\u51fa\u4f5c\u4e3a\u957f\u6548 GLP-1R \u6fc0\u52a8\u5242\u7528\u4e8e\u63a7\u5236\u7cd6\u5c3f\u75c5\u548c\u51cf\u80a5\u7684\u6f5c\u529b<\/h2><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-027104d elementor-section-boxed elementor-section-height-default elementor-section-height-default smart-sticky-default\" data-id=\"027104d\" data-element_type=\"section\">\r\n\t\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\r\n\t\t\t\t\r\n\t\t\t\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a846582\" data-id=\"a846582\" data-element_type=\"column\">\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\r\n\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1b108c2 elementor-widget elementor-widget-text-editor\" data-id=\"1b108c2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"bwalignc\" style=\"text-align: center;\"><strong><i>\u81ea\u7136\u53d1\u751f\u7684\u7cd6\u5c3f\u75c5\u7334\u7684\u4e34\u5e8a\u524d\u7ed3\u679c\u5df2\u5728\u7f8e\u56fd\u7cd6\u5c3f\u75c5\u534f\u4f1a 84<sup>\u65e5<\/sup>\u00a0\u79d1\u5b66\u4f1a\u8bae\uff0c2024 \u5e74 6 \u6708 21 \u65e5\u81f3 24 \u65e5<\/i><\/strong><\/p><p class=\"bwalignc\" style=\"text-align: center;\"><strong><i>HighField \u8ba1\u5212\u4e8e 2024 \u5e74\u7b2c\u4e09\u5b63\u5ea6\u63d0\u4ea4 HFG1 \u7684\u7f8e\u56fd IND<\/i><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e59da4e elementor-widget-laptop__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"e59da4e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u4e2d\u56fd\u676d\u5dde\u2014\u20142024 \u5e74 6 \u6708 24 \u65e5\u2014\u2014HighField Biopharmaceuticals \u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u516c\u53f8\uff0c\u4f7f\u7528\u8102\u8d28\u7597\u6cd5\u6cbb\u7597\u764c\u75c7\u3001\u7cd6\u5c3f\u75c5\u548c\u5176\u4ed6\u75be\u75c5\uff0c\u8be5\u516c\u53f8\u4eca\u5929\u8868\u793a\uff0c\u81ea\u7136\u53d1\u751f\u7684\u7cd6\u5c3f\u75c5\u7334\u5b50\u5728\u4e00\u6b21\u6ce8\u5c04 HFG1 \u540e\uff0c\u5728\u4e3a\u671f\u4e24\u4e2a\u6708\u7684\u8bc4\u4f30\u671f\u5185\u4f53\u91cd\u51cf\u8f7b\uff0c\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\u964d\u4f4e\u3002\u8fd9\u4e9b\u6570\u636e\u5728\u7f8e\u56fd\u7cd6\u5c3f\u75c5\u534f\u4f1a (ADA) 84 \u4f1a\u8bae\u4e0a\u516c\u5e03<sup>\u65e5<\/sup>\u00a0\u79d1\u5b66\u4f1a\u8bae\u5c06\u4e8e 2024 \u5e74 6 \u6708 21 \u65e5\u81f3 24 \u65e5\u5728\u4f5b\u7f57\u91cc\u8fbe\u5dde\u5965\u5170\u591a\u4e3e\u884c\u3002<\/p><div class=\"bw-release-story\"><p>HFG1 \u662f\u4e00\u79cd\u57fa\u4e8e mRNA \u7684 GLP-1R \u6fc0\u52a8\u5242\uff0c\u7f16\u7801 GLP-1 \u7c7b\u4f3c\u7269\u548c\u4eba\u7c7b FcRn pH \u654f\u611f\u7ed3\u5408\u5242\u7684\u878d\u5408\u86cb\u767d\u3002mRNA \u88ab\u88c5\u8f7d\u5728\u4e13\u6709\u8102\u8d28\u7eb3\u7c73\u7ed3\u6784\u9897\u7c92 (LNP) \u4e2d\uff0c\u4e13\u4e3a\u76ae\u4e0b\u7ed9\u836f\u548c\u5c40\u90e8 mRNA \u9012\u9001\u800c\u8bbe\u8ba1\u3002\u8868\u8fbe\u7684\u86cb\u767d\u8d28\u88ab\u5206\u6ccc\u5e76\u5206\u5e03\u5230\u5168\u8eab\u5faa\u73af\u4e2d\u3002<\/p><p>\u6458\u8981\u6807\u9898\u4e3a\u00a0<a href=\"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/1860-LB\/155554\/1860-LB-Preliminary-Study-of-Efficacy-and-Duration?searchresult=1\" target=\"_blank\" rel=\"nofollow noopener\" shape=\"rect\">\u201c\u57fa\u4e8e mRNA \u7684 GLP-1R \u6fc0\u52a8\u5242\u5bf9\u7cd6\u5c3f\u75c5\u7334\u7684\u7597\u6548\u548c\u6301\u7eed\u65f6\u95f4\u7684\u521d\u6b65\u7814\u7a76\u201d\uff0c<\/a>\u00a0\u53d1\u8868\u5728 ADA \u671f\u520a\u7f51\u7ad9\u4e0a\u00a0<i>\u7cd6\u5c3f\u75c5<\/i>HighField CEO\u517cScientific\u521b\u59cb\u4eba\u5f90\u5b87\u5b8f\u535a\u58eb\u5728\u4f1a\u4e0a\u4f5c\u4e86\u00a0<a href=\"https:\/\/highfieldbio.com\/wp-content\/uploads\/2024\/06\/HIGHFIELD_ADA-poster-2024.pdf\" target=\"_blank\" rel=\"nofollow noopener\" shape=\"rect\">\u5b8c\u6574\u6d77\u62a5<\/a>.<\/p><p>\u201c\u6211\u4eec\u5bf9\u7ed3\u679c\u611f\u5230\u975e\u5e38\u9f13\u821e\uff0c\u6211\u4eec\u8ba1\u5212\u5728\u4eca\u5e74\u7b2c\u4e09\u5b63\u5ea6\u63d0\u4ea4\u7f8e\u56fd IND\uff0c\u201d\u5f90\u535a\u58eb\u8bf4\u3002\u201c\u6211\u4eec\u7684 LNP \u91c7\u7528\u819c\u7a33\u5b9a\u7ed3\u6784\u5f00\u53d1\u3002\u4e0e\u7528\u4e8e mRNA \u75ab\u82d7\u7684\u4f20\u7edf LNP \u4e0d\u540c\uff0c\u5b83\u4eec\u5728\u50a8\u5b58\u548c\u6ce8\u5c04\u540e\u66f4\u7a33\u5b9a\u3002\u8f6c\u57fa\u56e0\u7684\u4ea7\u751f\u66f4\u52a0\u6301\u4e45\uff0c\u4f7f GLP-1R \u6fc0\u52a8\u5242\u6d3b\u6027\u80fd\u591f\u6301\u7eed\u6570\u5468\u548c\u6570\u6708\u3002\u56e0\u6b64\uff0c\u4e0e\u73b0\u6709\u7684 GLP-1 \u4ea7\u54c1\u76f8\u6bd4\uff0c\u6240\u9700\u7684\u6ce8\u5c04\u6b21\u6570\u8981\u5c11\u5f97\u591a\u3002\u201d<\/p><p>\u6ce8\u5c04 HFG1 \u540e\uff0c\u7814\u7a76\u4eba\u5458\u5bf9\u7334\u5b50\u8fdb\u884c\u4e86\u5bc6\u5207\u76d1\u6d4b\u3002\u7334\u5b50\u6ca1\u6709\u8868\u73b0\u51fa\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u3002\u7136\u800c\uff0c\u6ce8\u5c04\u540e\u7684\u7b2c\u4e00\u5468\uff0c\u5b83\u4eec\u7684\u98df\u6b32\u6709\u6240\u4e0b\u964d\uff0c\u4e4b\u540e\u98df\u6b32\u6062\u590d\u6b63\u5e38\u3002\u4f53\u91cd\u51cf\u8f7b\u548c A1C (HbA1c) \u4e0b\u964d\u660e\u663e\u3002<\/p><p><strong>\u5173\u4e8e HighField \u751f\u7269\u5236\u836f<\/strong><\/p><p>HighField \u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u9488\u5bf9\u514d\u75ab\u80bf\u7624\u5b66\u548c\u5176\u4ed6\u75be\u75c5\u6cbb\u7597\u7684\u8102\u8d28\u4f53\u7ed3\u6784\u7684\u65b0\u5e94\u7528\u3002\u8be5\u516c\u53f8\u8fd8\u62e5\u6709\u4e00\u4e2a\u7814\u53d1\u4e2d\u5fc3\u548c\u4e00\u4e2a\u7b26\u5408 GMP \u7684\u751f\u4ea7\u8bbe\u65bd\u3002HighField \u7684\u4e3b\u8981\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\u662f HFK16\uff0c\u4e00\u79cd\u836f\u7269\u5305\u5c01\u7684\u514d\u75ab\u8c03\u8282\u8102\u8d28\u4f53\u3002\u8be5\u516c\u53f8\u7684\u4ea7\u54c1\u7ebf\u8fd8\u5305\u62ec\u4e00\u4e2a ADC \u5e73\u53f0\uff0c\u8be5\u5e73\u53f0\u7531\u7528\u4e8e\u5b9e\u4f53\u7624\u7684\u836f\u7269\u5305\u5c01\u514d\u75ab\u8102\u8d28\u4f53\u4ee5\u53ca\u7528\u4e8e\u57fa\u56e0\u4f20\u9012\u548c\u57fa\u56e0\u6cbb\u7597\u7684 LNP \u7597\u6cd5\u7ec4\u6210\u3002\u6709\u5173\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee https:\/\/highfieldbio.com<\/p><\/div><div class=\"bw-release-contact\"><p><strong>\u8054\u7cfb\u65b9\u5f0f<\/strong><\/p><p>\u5a92\u4f53\u8054\u7cfb\u65b9\u5f0f\uff1a<br \/>\u4e39\u00b7\u57c3\u62c9\u7c73\u5b89<br \/>Opus \u751f\u7269\u6280\u672f\u901a\u8baf<br \/><a href=\"mailto:danieleramian@comcast.net\" target=\"_blank\" rel=\"nofollow noopener\" shape=\"rect\">danieleramian@comcast.net<\/a><br \/>425-306-8716<\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>HighField Biopharmaceuticals \u57fa\u4e8e mRNA \u7684 HFG1 \u663e\u793a\u51fa\u4f5c\u4e3a\u957f\u6548 GLP-1R \u6fc0\u52a8\u5242\u7528\u4e8e\u63a7\u5236\u7cd6\u5c3f\u75c5\u548c\u51cf\u80a5\u7684\u6f5c\u529b \u5728 2024 \u5e74 6 \u6708 21 \u65e5\u81f3 24 \u65e5\u4e3e\u884c\u7684\u7f8e\u56fd\u7cd6\u5c3f\u75c5\u534f\u4f1a\u7b2c 84 \u5c4a\u79d1\u5b66\u4f1a\u8bae\u4e0a\u4ecb\u7ecd\u4e86\u81ea\u7136\u53d1\u751f\u7684\u7cd6\u5c3f\u75c5\u7334\u7684\u4e34\u5e8a\u524d\u7ed3\u679c HighField \u8ba1\u5212\u5728 2024 \u5e74\u7b2c\u4e09\u5b63\u5ea6\u4e3a HFG1 \u63d0\u4ea4\u7f8e\u56fd IND \u4e2d\u56fd\u676d\u5dde\u2014\u20142024 \u5e74 6 \u6708 24 \u65e5\u2014\u2014HighField Biopharmaceuticals\uff0c\u4e00\u5bb6\u4e34\u5e8a [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[22],"tags":[],"class_list":["post-6626","post","type-post","status-publish","format-standard","hentry","category-press-release"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>HighField Biopharmaceuticals\u2019 mRNA-based HFG1\u00a0Demonstrates Potential as a Longer Acting GLP-1R Agonist\u00a0for Diabetic Control and Weight Loss - HighField Biopharmaceuticals<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/highfieldbio.com\/zh\/2024\/06\/24\/highfield-biopharmaceuticals-mrna-based-hfg1-demonstrates-potential-as-a-longer-acting-glp-1r-agonist-for-diabetic-control-and-weight-loss\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HighField Biopharmaceuticals\u2019 mRNA-based HFG1\u00a0Demonstrates Potential as a Longer Acting GLP-1R Agonist\u00a0for Diabetic Control and Weight Loss - HighField Biopharmaceuticals\" \/>\n<meta property=\"og:description\" content=\"HighField Biopharmaceuticals\u2019 mRNA-based HFG1 Demonstrates Potential as a Longer Acting GLP-1R Agonist for Diabetic Control and Weight Loss Preclinical results in naturally occurred diabetic monkeys were presented at the American Diabetes Association 84th\u00a0Scientific Sessions, June 21-24, 2024 HighField plans on filing a U.S. IND for HFG1 in Q3\/2024 HANGZHOU, China&#8211;June 24, 2024&#8211;HighField Biopharmaceuticals, a clinical [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/highfieldbio.com\/zh\/2024\/06\/24\/highfield-biopharmaceuticals-mrna-based-hfg1-demonstrates-potential-as-a-longer-acting-glp-1r-agonist-for-diabetic-control-and-weight-loss\/\" \/>\n<meta property=\"og:site_name\" content=\"HighField Biopharmaceuticals\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-24T12:13:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-12-18T14:18:05+00:00\" \/>\n<meta name=\"author\" content=\"PJWCreative\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" 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