{"id":6207,"date":"2024-01-08T03:37:00","date_gmt":"2024-01-08T11:37:00","guid":{"rendered":"https:\/\/highfieldbio.com\/?p=6207"},"modified":"2024-12-18T06:14:41","modified_gmt":"2024-12-18T14:14:41","slug":"highfield-biopharmaceuticals-hf1k16-phase-1a-data-suggests-the-new-immuno-oncology-drug-is-safe-well-tolerated-and-efficacious-in-solid-tumors","status":"publish","type":"post","link":"https:\/\/highfieldbio.com\/zh\/2024\/01\/08\/highfield-biopharmaceuticals-hf1k16-phase-1a-data-suggests-the-new-immuno-oncology-drug-is-safe-well-tolerated-and-efficacious-in-solid-tumors\/","title":{"rendered":"HighField Biopharmaceuticals HF1K16 1a \u671f\u6570\u636e\u8868\u660e\u65b0\u578b\u514d\u75ab\u80bf\u7624\u836f\u7269\u5bf9\u5b9e\u4f53\u7624\u5b89\u5168\u3001\u8010\u53d7\u6027\u826f\u597d\u4e14\u6709\u6548"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"6207\" class=\"elementor elementor-6207\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7c3df96 elementor-section-boxed elementor-section-height-default elementor-section-height-default smart-sticky-default\" data-id=\"7c3df96\" data-element_type=\"section\">\r\n\t\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\r\n\t\t\t\t\r\n\t\t\t\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f09d554\" data-id=\"f09d554\" data-element_type=\"column\">\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\r\n\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-33706a9 elementor-widget elementor-widget-spacer\" data-id=\"33706a9\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f9ed22 elementor-widget elementor-widget-udesign_widget_heading\" data-id=\"7f9ed22\" data-element_type=\"widget\" data-widget_type=\"udesign_widget_heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"title-wrapper  title-cross title-center\"><p class=\"title elementor-heading-title\">2024 \u5e74 1 \u6708 8 \u65e5 | HighField Bio \u65b0\u95fb\u7a3f<\/p><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b2ac3db elementor-widget elementor-widget-spacer\" data-id=\"b2ac3db\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ac618a2 elementor-widget elementor-widget-udesign_widget_heading\" data-id=\"ac618a2\" data-element_type=\"widget\" data-widget_type=\"udesign_widget_heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"title-wrapper  title-center\"><h2 class=\"title elementor-heading-title\">HighField Biopharmaceuticals HF1K16 1a \u671f\u6570\u636e\u8868\u660e\u65b0\u578b\u514d\u75ab\u80bf\u7624\u836f\u7269\u5bf9\u5b9e\u4f53\u7624\u5b89\u5168\u3001\u8010\u53d7\u6027\u826f\u597d\u4e14\u6709\u6548<\/h2><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-027104d elementor-section-boxed elementor-section-height-default elementor-section-height-default smart-sticky-default\" data-id=\"027104d\" data-element_type=\"section\">\r\n\t\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\r\n\t\t\t\t\r\n\t\t\t\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a846582\" data-id=\"a846582\" data-element_type=\"column\">\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\r\n\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e59da4e elementor-widget-laptop__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"e59da4e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u4e2d\u56fd\u676d\u5dde - 2024 \u5e74 1 \u6708 8 \u65e5 - HighField Biopharmaceuticals \u662f\u4e00\u5bb6\u4f7f\u7528\u8102\u8d28\u7597\u6cd5\u6cbb\u7597\u764c\u75c7\u7684\u4e34\u5e8a\u9636\u6bb5\u514d\u75ab\u80bf\u7624\u5b66\u516c\u53f8\uff0c\u4eca\u5929\u5ba3\u5e03\u5df2\u5b8c\u6210 HF1K16 \u7684 1a \u671f\u7814\u7a76\u3002\u5728\u6cbb\u7597\u60a3\u6709\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u7684\u60a3\u8005\u65f6\uff0c\u6570\u636e\u8868\u660e\uff0c\u8be5\u836f\u7269\u4f5c\u4e3a\u5355\u4e00\u836f\u7269\u7ed9\u836f\u65f6\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5728\u6700\u9ad8\u5242\u91cf\u6c34\u5e73\u4e0b\u4ec5\u51fa\u73b0\u4e00\u79cd\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\u3002 HF1K16\u662f\u4e00\u79cd\u836f\u7269\u5c01\u88c5\u7684\u542b\u6709\u5168\u53cd\u5f0f\u89c6\u9ec4\u9178\u7684\u514d\u75ab\u8c03\u8282\u8102\u8d28\u4f53\u3002<\/p><div class=\"bw-release-story\"><p>HighField \u9996\u5e2d\u6267\u884c\u5b98 Yuhong Xu \u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u5bf9\u4e0e\u6cbb\u7597\u6301\u7eed\u65f6\u95f4\u76f8\u5173\u7684\u7ed3\u679c\u611f\u5230\u7279\u522b\u9f13\u821e\uff0c\u56e0\u4e3a\u836f\u7269\u53ef\u4ee5\u957f\u671f\u8010\u53d7\u3002\u201d \u201c\u4e00\u540d\u795e\u7ecf\u80f6\u8d28\u7624\u60a3\u8005\u7ecf\u8fc7 10 \u4e2a\u6708\u7684\u6cbb\u7597\u540e\u5b8c\u5168\u7f13\u89e3\uff0c\u5e76\u7ee7\u7eed\u6cbb\u7597\u4e24\u5e74\uff0c\u5e76\u4e14\u6ca1\u6709\u764c\u75c7\u3002\u53e6\u4e00\u4f4d\u60a3\u6709 IV \u7ea7\u5341\u4e8c\u6307\u80a0\u764c\u7684\u60a3\u8005\u75c5\u60c5\u7a33\u5b9a\u6301\u7eed\u4e86 5 \u4e2a\u591a\u6708\u3002\u201d<\/p><p>\u81ea2022\u5e74\u5f00\u59cb\uff0c\u5171\u670914\u540d\u60a3\u6709\u5404\u79cd\u96be\u6cbb\u6027\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\uff08\u5982\u795e\u7ecf\u80f6\u8d28\u7624\u3001\u80c3\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u809d\u764c\u3001\u80ba\u764c\u548c\u5375\u5de2\u764c\uff09\u7684\u60a3\u8005\u5728\u4e2d\u56fd\u63a5\u53d7\u4e86HF1K16\u7684\u6cbb\u7597\uff0c\u4e14\u5242\u91cf\u4e0d\u65ad\u589e\u52a0\u3002<\/p><p>\u603b\u4f53\u800c\u8a00\uff0c\u60a3\u8005\u7684\u75be\u75c5\u63a7\u5236\u7387\u7ea6\u4e3a35%\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e3a8.5\u4e2a\u6708\u3002\u6700\u957f\u751f\u5b58\u671f\u5df2\u8d85\u8fc724\u4e2a\u6708\uff0c\u5176\u4e2d5\u540d\u60a3\u8005\u751f\u5b58\u65f6\u95f4\u8d85\u8fc710\u4e2a\u6708\u3002<\/p><p>\u201c\u8003\u8651\u5230\u7814\u7a76\u4e2d\u60a3\u8005\u7684\u75be\u75c5\u72b6\u51b5\uff0c35% \u7684\u5355\u836f\u6cbb\u7597\u7ed3\u679c\u7684\u75be\u75c5\u63a7\u5236\u7387\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\uff0c\u201d\u5f90\u535a\u58eb\u8bf4\u3002 \u201c\u6b64\u5916\uff0c\u6211\u4eec\u53d1\u73b0\u6cbb\u7597\u540e\u60a3\u8005\u7684\u9aa8\u9ad3\u7ec6\u80de\u548c T \u7ec6\u80de\u8c31\u53d1\u751f\u4e86\u663e\u7740\u53d8\u5316\u3002\u7531\u4e8e\u5b83\u663e\u793a\u51fa\u65b0\u7684\u673a\u5236\u548c\u51fa\u8272\u7684\u5b89\u5168\u6027\uff0c\u6211\u4eec\u7684\u4e0b\u4e00\u6b65\u662f\u63a2\u7d22 HF1K16 \u4e0e\u5316\u7597\u548c\u5176\u4ed6\u514d\u75ab\u80bf\u7624\u7597\u6cd5\u7684\u7ed3\u5408\u3002\u201d<\/p><p>HF1K16 \u662f ATRA \u7684\u72ec\u7279\u8102\u8d28\u4f53\u7ed3\u6784\uff0cATRA \u662f\u7ef4\u751f\u7d20 A \u7684\u5c0f\u5206\u5b50\u4ee3\u8c22\u7269\u3002\u5b83\u901a\u8fc7\u8f93\u6ce8\u7ed9\u836f\uff0c\u7a7f\u8fc7\u8840\u6d41\u5e76\u6e17\u900f\u80bf\u7624\u5fae\u73af\u5883\u3002 ATRA \u88ab\u91ca\u653e\u5e76\u542f\u52a8\u9aa8\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de (MDSC) \u7684\u6210\u719f\u3002<\/p><p>MDSC \u662f\u672a\u5206\u5316\u7684\u672a\u6210\u719f\u9aa8\u9ad3\u7ec6\u80de\u3002 ATRA \u4fc3\u8fdb MDSC \u6210\u719f\u5e76\u5206\u5316\u4e3a\u529f\u80fd\u7ec6\u80de\uff0c\u4f8b\u5982\u6811\u7a81\u72b6\u7ec6\u80de\uff0c\u7136\u540e\u53ec\u5524 T \u7ec6\u80de\u653b\u51fb\u764c\u75c7\u3002<\/p><p>\u6709\u5173 1a \u671f\u5f00\u653e\u6807\u7b7e\u8bd5\u9a8c\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u53c2\u9605\u00a0<a href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fstudy%2FNCT05388487%3Fintr%3DHF1K16%26rank%3D2&amp;esheet=53878063&amp;newsitemid=20240108874322&amp;lan=en-US&amp;anchor=NCT05388487&amp;index=1&amp;md5=9f00094049f0901369b53a8dac1a3687\" target=\"_blank\" rel=\"nofollow noopener\" shape=\"rect\">NCT05388487<\/a>\u00a0\u5728\u4e34\u5e8a\u8bd5\u9a8c.gov\u3002<\/p><p><b>\u5173\u4e8e HighField \u751f\u7269\u5236\u836f<br \/><\/b>HighField \u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u514d\u75ab\u80bf\u7624\u5b66\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u8102\u8d28\u4f53\u7ed3\u6784\u7684\u65b0\u9896\u5e94\u7528\uff0c\u4ee5\u98a0\u8986\u73b0\u6709\u7684\u514d\u75ab\u80bf\u7624\u5b66\u6280\u672f\u3002\u516c\u53f8\u62e5\u6709\u7814\u53d1\u4e2d\u5fc3\u548c\u7b26\u5408GMP\u6807\u51c6\u7684\u751f\u4ea7\u8bbe\u65bd\u3002 HighField \u7684\u4e3b\u5bfc\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\u662f HF1K16\uff0c\u8fd9\u662f\u4e00\u79cd\u836f\u7269\u5c01\u88c5\u7684\u514d\u75ab\u8c03\u8282\u8102\u8d28\u4f53\uff0c\u542b\u6709\u5168\u53cd\u5f0f\u89c6\u9ec4\u9178\uff0c\u9776\u5411\u9aa8\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de\uff0c\u7528\u4e8e\u6cbb\u7597\u5b9e\u4f53\u7624\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u00a0<a href=\"https:\/\/highfieldbio.com\/zh\/\">https:\/\/highfieldbio.com<\/a><\/p><\/div><div class=\"bw-release-contact\"><h2>\u8054\u7cfb\u65b9\u5f0f<\/h2><p>\u5a92\u4f53\u8054\u7cfb\u65b9\u5f0f\uff1a<br \/>\u4e39\u00b7\u57c3\u62c9\u7c73\u5b89<br \/>Opus \u751f\u7269\u6280\u672f\u901a\u8baf<br \/><a href=\"mailto:danieleramian@comcast.net\" target=\"_blank\" rel=\"nofollow noopener\" shape=\"rect\">danieleramian@comcast.net<\/a><br \/>425-306-8716<\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>HighField Biopharmaceuticals HF1K16 1a \u671f\u6570\u636e\u8868\u660e\u65b0\u578b\u514d\u75ab\u80bf\u7624\u836f\u7269\u5bf9\u5b9e\u4f53\u7624\u5b89\u5168\u3001\u8010\u53d7\u6027\u826f\u597d\u4e14\u6709\u6548 \u4e2d\u56fd\u676d\u5dde \u2013 2024 \u5e74 1 \u6708 8 \u65e5 \u2013 HighField Biopharmaceuticals\uff0c\u4e00\u5bb6\u4f7f\u7528\u8102\u8d28\u7597\u6cd5\u6cbb\u7597\u4e34\u5e8a\u9636\u6bb5\u7684\u514d\u75ab\u80bf\u7624\u5b66\u516c\u53f8\u764c\u75c7\uff0c\u4eca\u5929\u5ba3\u5e03\u5df2\u5b8c\u6210 HF1K16 \u7684 1a \u671f\u7814\u7a76\u3002\u6cbb\u7597\u60a3\u6709\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u7684\u60a3\u8005\uff0c\u6570\u636e\u8868\u660e [...]<\/p>","protected":false},"author":1,"featured_media":6212,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[22],"tags":[],"class_list":["post-6207","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.0 - 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1a Data Suggests the New Immuno-Oncology Drug is Safe, Well-Tolerated and Efficacious in Solid Tumors HANGZHOU, China&#8211;January 8, 2024&#8211;HighField Biopharmaceuticals, a clinical stage immuno-oncology company using lipid-based therapeutics to treat cancer, announced today it has completed its Phase 1a study of HF1K16. 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