{"id":6660,"date":"2024-07-02T15:17:39","date_gmt":"2024-07-02T22:17:39","guid":{"rendered":"https:\/\/highfieldbio.com\/?page_id=6660"},"modified":"2026-07-08T16:06:35","modified_gmt":"2026-07-08T23:06:35","slug":"pipelines","status":"publish","type":"page","link":"https:\/\/highfieldbio.com\/zh\/pipelines\/","title":{"rendered":"\u7ba1\u9053"},"content":{"rendered":"
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\u7ba1\u9053<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u57fa\u56e0\u6cbb\u7597<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"HIGHFIELD_onelips_horizontal\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t
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HighField\u7ba1\u9053<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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HighField \u7ba1\u9053\u4ea7\u54c1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t
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K16\uff1a<\/strong> \u514d\u75ab\u8c03\u8282\u5242 <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t
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\u66f4\u65b0\uff1a <\/span>\u5728I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cK16\u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\uff0c\u5bf9\u63a5\u53d7\u8fc7\u5927\u91cf\u6cbb\u7597\u7684\u590d\u53d1\u6027\u80f6\u8d28\u7624\u60a3\u8005\u663e\u793a\u51fa69%\u7684\u75be\u75c5\u63a7\u5236\u7387\u3002\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5373\u5c06\u542f\u52a8\uff0c\u4ee5\u8bc4\u4f30K16\u8054\u5408\u6807\u51c6\u6cbb\u7597(SOC)\u5bf9\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4ee5\u53ca\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/span><\/em><\/strong><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t
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K16\u7ed3\u5408\u8102\u8d28\u53cc\u5c42\u7ed3\u6784\u548c\u5168\u53cd\u5f0f\u7ef4\u7532\u9178\uff08ATRA\uff09\uff0c\u9ad8\u6d53\u5ea6\u7684ATRA\u53ef\u8bf1\u5bfc\u672a\u6210\u719f\u514d\u75ab\u7ec6\u80de\uff08MDSC\uff09\u6210\u4e3a\u6210\u719f\u3001\u6d3b\u8dc3\u7684\u514d\u75ab\u7ec6\u80de\uff08\u6811\u7a81\u72b6\u7ec6\u80de\uff09\u3002<\/h4>

MDSC\u5177\u6709\u514d\u75ab\u6291\u5236\u6d3b\u6027\uff0c\u56e0\u6b64\u5c06\u5176\u8f6c\u5316\u4e3a\u6210\u719f\u7684\u514d\u75ab\u7ec6\u80de\u4f1a\u4ea7\u751f\u6297\u764c\u4f5c\u7528\u3002\u764c\u75c7\u60a3\u8005\u4f53\u5185\u7684 MDSC \u79ef\u7d2f\u5f80\u5f80\u8d85\u51fa\u5065\u5eb7\u4eba\u7684\u6c34\u5e73\uff0c\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u4e5f\u88ab\u79f0\u4e3a\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAM\uff09\u3002\u8fd9\u662f\u5bf9\u764c\u75c7\u60a3\u8005\u514d\u75ab\u7cfb\u7edf\u7684\u4e00\u79cd\u7279\u522b\u9634\u9669\u7684\u6291\u5236\uff0c\u5982\u679c\u80fd\u6d88\u9664\u8fd9\u7c7b\u6291\u5236\u4f5c\u7528\uff0c\u5c31\u4f1a\u5bf9\u80bf\u7624\u6cbb\u7597\u4ea7\u751f\u6df1\u8fdc\u7684\u5f71\u54cd\u3002\u00a0<\/p>

ATRA \u4e3a\u7ef4\u751f\u7d20 A \u7684\u4ee3\u8c22\u4ea7\u7269\uff0c\u8f7d\u6709\u9ad8\u5242\u91cfATRA\u7684\u8102\u8d28\u7ed3\u6784\u5df2\u7ecf\u5728I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u88ab\u8bc1\u660e\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u800c\u4e14\u5728\u665a\u671f\u5b9e\u4f53\u7624\u75c5\u4eba\u4e2d\u5f00\u5c55\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8fd8\u63d0\u793a\u4e86K16\u5355\u836f\u6cbb\u7597\u8111\u80f6\u8d28\u7624\u7684\u6709\u6548\u6027\u3002\u00a0<\/p>

\u9664\u6b64\u4e4b\u5916\uff0c\u9274\u4e8e\u5176\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u72ec\u7279\u7684MDSC\u4f5c\u7528\u673a\u5236\uff0cK16 \u4e5f\u53ef\u80fd\u662f\u4e0e\u5176\u4ed6\u764c\u75c7\u7597\u6cd5\u8054\u5408\u4f7f\u7528\u7684\u5019\u9009\u836f\u7269\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t

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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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K1\uff1a<\/strong> ADCplex\u2122\u8102\u8d28\u6297\u4f53\u836f\u7269\u590d\u5408\u7269<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t
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\u6297\u4f53\u5076\u8054\u7684\u8f7d\u836f\u8102\u8d28\u4f53\uff08\u5373\u514d\u75ab\u8102\u8d28\u4f53\uff09\u4ee3\u8868\u4e86\u65b0\u4e00\u4ee3\u7684\u9776\u5411\u80bf\u7624\u7ec6\u80de\u7684\u836f\u7269\u6cbb\u7597\u7684\u65b9\u5411\u00a0<\/h4>

\u6211\u4eec\u7684 ADCplex \u5e73\u53f0\u6bd4\u6297\u4f53-\u836f\u7269\u5076\u8054\u7269 (ADC) \u7b49\u5176\u4ed6\u9776\u5411\u6cbb\u7597\u836f\u7269\u5177\u6709\u66f4\u5927\u7684\u6709\u6548\u8f7d\u8377\u5bb9\u91cf\u548c\u7075\u6d3b\u6027\u3002\u8fd9\u4e0d\u4ec5\u63d0\u9ad8\u4e86\u5b89\u5168\u6027\uff0c\u8fd8\u6539\u5584\u4e86\u6cbb\u7597\u6548\u679c\uff0c\u4ece\u800c\u6269\u5927\u4e86\u6cbb\u7597\u7a97\u53e3\u3002<\/p>

Kl \u662f\u6211\u4eec\u7ba1\u7ebf\u4e2d\u6b63\u5728\u5f00\u53d1\u7684\u6700\u5148\u8fdb ADCplex\u3002\u5b83\u5305\u542b\u9488\u5bf9 HER2 \u7684\u6297\u4f53\u8102\u8d28 TL01\u3002\u5c01\u88c5\u7684\u836f\u7269\u6709\u6548\u8f7d\u8377\u662f\u963f\u9709\u7d20\u3002\u5728\u52a8\u7269\u6a21\u578b\u4e2d\uff0cK1 \u7684\u6297\u80bf\u7624\u6d3b\u6027\u9ad8\u4e8e\u9886\u5148\u836f\u7269\uff0c\u4f8b\u5982 T-DM1 \u548c DS-8201a\u3002\u91cd\u8981\u7684\u662f\uff0cK1 \u6ca1\u6709\u8fd9\u4e9b\u5176\u4ed6\u836f\u7269\u4e2d\u53d1\u73b0\u7684\u76f8\u5173\u5316\u5b66\u8010\u836f\u6027\u4f5c\u7528\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u66f4\u65b0\uff1a <\/strong>\u5728I\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0cK1\u572830\u6beb\u514b\/\u5e73\u65b9\u7c73\u7684\u963f\u9709\u7d20\u5242\u91cf\u6c34\u5e73\u4e0b\u4e5f\u5df2\u88ab\u8bc1\u660e\u662f\u5b89\u5168\u7684\u3002\u9996\u4f8b\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u5df2\u83b7\u5f97\u8d85\u8fc76\u4e2a\u6708\u7684PFS\u3002<\/em><\/span><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t
\r\n\t\t\t\t\t
\r\n\t\t\t\n\t\n<\/svg>\t\t<\/div>\r\n\t\t\t\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

K5:<\/strong> ADCplex\u2122\u8102\u8d28\u6297\u4f53\u836f\u7269\u590d\u5408\u7269<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t
\r\n\t\t\t\t\t\t\t\t
\r\n\t\t\t\t\r\n\t\t\t\t\t\t\t\t
\r\n\r\n\t\t\t\t\r\n\t\t\t\t
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\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t
\r\n\r\n\t\t\t\t\r\n\t\t\t\t
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\n\t\t\t\t
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K5 is our next-generation ADCplex targeting HER2 and EGFR, armed with three distinct payloads\u2014a TOP1 inhibitor, a TOP2 inhibitor, and a microtubule polymerization inhibitor\u2014designed for the treatment of solid tumors. The antibodies on the surface of the liposome enables efficient internalization and coordinated delivery of the payloads, enhancing antitumor efficacy and overcoming resistance mechanisms. Notably, K5 has demonstrated robust activity in preclinical models, including those resistant to conventional ADCs, while exhibiting a favorable safety profile.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t

\r\n\t\t\t\t\t
\r\n\t\t\t\n\t\n<\/svg>\t\t<\/div>\r\n\t\t\t\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t

HF50\uff1a<\/strong> TCEplex\u2122 T\u7ec6\u80de\u63a5\u5408\u590d\u5408\u7269<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t
\r\n\t\t\t\t\t\t\t\t
\r\n\t\t\t\t\r\n\t\t\t\t\t\t\t\t
\r\n\r\n\t\t\t\t\r\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

HF50 \u76ee\u524d\u5904\u4e8e I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002\u8fd9\u9879\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u5f00\u653e\u6807\u7b7e\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u5c06\u8bc4\u4f30\u5176\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u3001\u514d\u75ab\u539f\u6027\u548c\u521d\u6b65\u7597\u6548\u3002\u7814\u7a76\u8bbe\u8ba1\u548c\u8054\u7cfb\u65b9\u5f0f\u8be6\u60c5\u8bf7\u8bbf\u95ee ClinicalTrials.gov (NCT06822998)\u3002<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t

\r\n\r\n\t\t\t\t\r\n\t\t\t\t
\r\n\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t
\n\t\t\t\t
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\u6fc0\u6d3bT\u7ec6\u80de\u5e76\u4fc3\u4f7f\u5176\u4f5c\u7528\u4e8e\u80bf\u7624\u7ec6\u80de\uff0c\u9ad8\u6548\u4f4e\u6bd2\u5730\u5b9e\u73b0\u96be\u6cbb\u6027\u80bf\u7624\u7684\u6740\u4f24<\/h4>

HF50 \u662f\u4e00\u4e2a\u8102\u8d28\u53cc\u5c42\u7cfb\u7edf\uff0c\u9644\u7740\u4e24\u79cd\u4e0d\u540c\u7684\u6297\u4f53\u3002\u7b2c\u4e00\u79cd\u6297\u4f53\u9488\u5bf9\u514d\u75ab T \u7ec6\u80de\uff0c\u7b2c\u4e8c\u79cd\u6297\u4f53\u9488\u5bf9\u8868\u8fbe HER2 \u7684\u80bf\u7624\u3002\u8be5\u7cfb\u7edf\u88ab\u79f0\u4e3a T \u7ec6\u80de\u8854\u63a5\u590d\u5408\u7269 (TCEplex)\u3002HF50 \u8fd8\u643a\u5e26\u6709\u6548\u8f7d\u8377\u96f7\u897f\u83ab\u5fb7 (Resiquimod)\uff0c\u8fd9\u662f\u4e00\u79cd\u8c03\u8282 T \u7ec6\u80de\u5bf9\u764c\u7ec6\u80de\u53cd\u5e94\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u3002<\/p>

\u901a\u8fc7\u5bf9\u8fd9\u4e9b\u7ec4\u5206\u8fdb\u884c\u4f18\u5316\uff0c\u4ee5\u53ca\u5176\u4f5c\u7528\u4e8eT\u7ec6\u80de\u548c HER2\u8868\u8fbe\u80bf\u7624\u7ec6\u80de\u7684\u6548\u5e94\u4f18\u5316\uff0c\u4e34\u5e8a\u524d\u7814\u7a76\u8bc1\u660eHF50\u5728\u591a\u4e2aHER+ \u80bf\u7624\u6a21\u578b\u5747\u6709\u6548\u3002\u8fd9\u5c06\u662fResiquimod\u7684\u9996\u6b21\u5168\u8eab\u4f7f\u7528\uff0c\u5176\u5bf9\u514d\u75abT\u7ec6\u80de\u7684\u523a\u6fc0\u4f5c\u7528\u5927\u5927\u589e\u5f3a\u4e86\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>

\u8fd9\u79cd\u8102\u8d28\u7cfb\u7edf\u53ef\u4e0e\u53cc\u7279\u5f02\u6027\u6297\u4f53\u76f8\u5ab2\u7f8e\uff0c\u4f46\u5728\u8bb8\u591a\u65b9\u9762\u90fd\u8d85\u8fc7\u4e86\u5b83\u3002\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7684\u6297\u4f53\u7ed3\u5408\u65b9\u6848\u975e\u5e38\u6709\u9650\u3002\u65e0\u6cd5\u5b9e\u73b0\u6210\u5206\u7684\u6700\u4f73\u6bd4\u4f8b\u3002\u8fd9\u9650\u5236\u4e86\u6cbb\u7597\u7a97\u53e3\u53ca\u5176\u5728\u5b9e\u4f53\u80bf\u7624\u4e2d\u7684\u7597\u6548\u3002<\/p>

HF50 \u7684\u4f5c\u7528\u4e5f\u53ef\u4ee5\u4e0e\u589e\u5f3a\u578b CAR T \u8fdb\u884c\u7c7b\u6bd4\u3002CAR T \u6cbb\u7597\u7684\u76ee\u6807\u662f\u4f7f T \u7ec6\u80de\u8868\u8fbe\u6297\u80bf\u7624\u6297\u4f53\uff0c\u5bf9\u6bd4CAR T \u7ec6\u80de\u590d\u6742\u4e14\u6602\u8d35\u7684\u5de5\u827a\uff0cHF\u66f4\u4e3a\u4fbf\u6377\u548c\u7ecf\u6d4e\u3002\u6b64\u5916\uff0c\u514d\u75ab\u8c03\u8282\u7684\u6709\u6548\u8d1f\u8f7d\u5728\u589e\u5f3aT\u7ec6\u80de\u6d3b\u6027\u65b9\u9762\u4e5f\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t

\r\n\t\t\t\t\t
\r\n\t\t\t\n\t\n<\/svg>\t\t<\/div>\r\n\t\t\t\t\t\t\t
\r\n\t\t\t\t\r\n\t\t\t\t\t\t\t\t
\r\n\r\n\t\t\t\t\r\n\t\t\t\t
\r\n\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t
\n\t\t\t\t
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\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

HFG1\uff1a<\/strong> TCTplex\u2122 LNP-mRNA Complex<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t
\r\n\t\t\t\t\t\t\t\t
\r\n\t\t\t\t\r\n\t\t\t\t\t\t\t\t
\r\n\r\n\t\t\t\t\r\n\t\t\t\t
\r\n\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

HFG1 \u76ee\u524d\u6b63\u5728\u8fdb\u884c IND \u6388\u6743\u7814\u7a76\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0cHFG1 \u6240\u9700\u7684\u6ce8\u5c04\u6b21\u6570\u8fdc\u5c11\u4e8e\u73b0\u6709\u7684 GLP-1 \u4ea7\u54c1\uff0c\u540c\u65f6\u80fd\u591f\u63d0\u4f9b\u7a33\u6001\u6fc0\u52a8\u5242\u6d3b\u6027\u3002<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t
\r\n\r\n\t\t\t\t\r\n\t\t\t\t
\r\n\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

GLP-1R \u6fc0\u52a8\u5242\u957f\u671f\u8868\u8fbe\u7684\u57fa\u56e0\u6cbb\u7597\u00a0<\/h4>

HFG1 \u662f\u4e00\u79cd LNP-mRNA \u590d\u5408\u7269\uff0c\u53ef\u8868\u8fbe GLP-1R \u6fc0\u52a8\u5242\uff0c\u7528\u4e8e\u51cf\u80a5\u548c\u6cbb\u7597\u7cd6\u5c3f\u75c5\u3002HFG1 \u76ee\u524d\u5904\u4e8e IND \u9636\u6bb5\uff0c\u6b63\u5728\u7b49\u5f85\u7f8e\u56fd IND \u7533\u8bf7\u3002<\/p>

HFG1 \u7684 LNP \u590d\u5408\u7269\u7684\u6210\u5206\u7ecf\u8fc7\u7cbe\u5fc3\u6311\u9009\uff0c\u53ef\u5728\u4e0d\u4ea7\u751f\u660e\u663e\u514d\u75ab\u53cd\u5e94\u7684\u60c5\u51b5\u4e0b\u5ef6\u957f GLP-1R \u6fc0\u52a8\u5242\u7684\u8868\u8fbe\u65f6\u95f4\u3002HFG1 \u6240\u9700\u7684\u6ce8\u5c04\u6b21\u6570\u5c11\u4e8e\u73b0\u6709\u7684 GLP-1 \u4ea7\u54c1\uff0c\u540c\u65f6\u53ef\u63d0\u4f9b\u7a33\u6001\u6fc0\u52a8\u5242\u6d3b\u6027\u3002<\/p>

\u7528 HFG1 \u6cbb\u7597\u7684\u7cd6\u5c3f\u75c5\u7334\u5b50\u5728\u8f83\u957f\u65f6\u95f4\u5185\u8868\u73b0\u51fa\u4f53\u91cd\u51cf\u8f7b\u548c\u663e\u8457\u7684 A1C \u964d\u4f4e\u3002\u5728\u7ed9\u836f\u65f6\u8fbe\u5230\u521d\u59cb\u6d3b\u6027\u5cf0\u503c\u540e\uff0c\u89c2\u5bdf\u5230 GLP-1R \u6d3b\u6027\u548c A1C \u63a7\u5236\u7684\u7a33\u5b9a\u72b6\u6001\u81f3\u5c11\u6301\u7eed 60 \u5929\u3002\u8fd9\u610f\u5473\u7740\u5355\u6b21\u6ce8\u5c04\u5bf9\u4eba\u7c7b\u7684\u6cbb\u7597\u6d3b\u6027\u7ea6\u4e3a 4-5 \u4e2a\u6708\u3002\u9664\u4e86\u6ce8\u5c04\u65f6\u6700\u521d\u7684\u98df\u6b32\u4e0d\u632f\u5916\uff0c\u6ca1\u6709\u89c2\u5bdf\u5230\u4efb\u4f55\u884c\u4e3a\u53d8\u5316\u6216\u6bd2\u6027\u3002<\/p><\/div><\/div>

\u00a0<\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t
\r\n\t\t\t\t\t
\r\n\t\t\t\n\t\n<\/svg>\t\t<\/div>\r\n\t\t\t\t\t\t\t
\r\n\t\t\t\t\r\n\t\t\t\t\t\t\t\t
\r\n\r\n\t\t\t\t\r\n\t\t\t\t
\r\n\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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HFG12<\/strong> TCTplex\u2122 LNP-mRNA Complex<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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HFG1 \u76ee\u524d\u6b63\u5728\u8fdb\u884c IND \u6388\u6743\u7814\u7a76\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0cHFG1 \u6240\u9700\u7684\u6ce8\u5c04\u6b21\u6570\u8fdc\u5c11\u4e8e\u73b0\u6709\u7684 GLP-1 \u4ea7\u54c1\uff0c\u540c\u65f6\u80fd\u591f\u63d0\u4f9b\u7a33\u6001\u6fc0\u52a8\u5242\u6d3b\u6027\u3002<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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GLP-1R \u6fc0\u52a8\u5242\u957f\u671f\u8868\u8fbe\u7684\u57fa\u56e0\u6cbb\u7597\u00a0<\/h4>

HFG2 is an innovative in-vivo CAR-T therapy utilizing our proprietary TCT-LNP technology, specifically designed for the treatment of solid tumors. The therapy features a CD3\u00d7CD28 LNP structure that simultaneously delivers proprietary mRNA encoding a chimeric antigen receptor (CAR) to T cells, while engaging T cells via surface-conjugated humanized anti-CD3 and anti-CD28 antibodies. This dual-action design enables efficient T-cell activation, transduction, and targeted expansion of CAR-expressing T cells directly within the patient\u2018s body. As an off-the-shelf, transient, and rapidly acting therapy, HFG2 does not require lymphodepletion and can be redosed if needed. This offers a safer and more convenient alternative to traditional ex vivo CAR-T approaches, with the potential for improved tolerability and broader clinical accessibility.<\/p><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u57fa\u56e0\u6cbb\u7597\u4ea7\u54c1\u7ebf HighField \u4ea7\u54c1\u7ebf HighField \u4ea7\u54c1\u7ebf K16\uff1a\u514d\u75ab\u8c03\u8282\u5242 \u6700\u65b0\u8fdb\u5c55\uff1a\u5728 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cK16 \u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\uff0c\u5bf9\u63a5\u53d7\u8fc7\u5927\u91cf\u6cbb\u7597\u7684\u590d\u53d1\u6027\u80f6\u8d28\u7624\u60a3\u8005\u663e\u793a\u51fa 69% \u7684\u75be\u75c5\u63a7\u5236\u7387\u3002\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u7684 II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u5373\u5c06\u542f\u52a8\uff0c\u4ee5\u8bc4\u4f30 K16 \u4e0e [\u2026] \u8054\u5408\u6cbb\u7597\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_exactmetrics_skip_tracking":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-6660","page","type-page","status-publish","hentry"],"yoast_head":"\nPipelines - HighField Biopharmaceuticals<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/highfieldbio.com\/zh\/pipelines\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pipelines - HighField Biopharmaceuticals\" \/>\n<meta property=\"og:description\" content=\"Pipelines Gene Therapy HighField Pipeline HighField Pipeline Products K16: Immune Modulator Update: In Phase I, K16 has shown a 69% disease control rate as a single agent therapy for heavily pretreated patients with recurring glioma. 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